Alexander Kozik
Programming languages and Software:
Python,
Tcl/Tk,
PHP,
Perl,
R
Education:
Plant & Animal Genomes Conferences (PAG) 2002-2007, San Diego, CA;
PAG-14, January 14-18, 2006:
PAG-13, January 15-19, 2005:
PAG-12, January 10-14, 2004:
PAG-11, January 11-15, 2003:
PAG-10, January 12-16, 2002:
Bioinformatics Specialist
Genome and Biomedical Sciences Facility
451 East Health Sciences Drive
University of California
Davis, CA 95616-8816
Email: akozik@atgc.org
Web: http://www.atgc.org/
Background:
Selected computer programs developed by me are available at:
http://www.atgc.org/
http://www.atgc.org/Py_ContigViewer/
http://www.atgc.org/GenomePixelizer/
http://www.atgc.org/PhyloGrapher/
http://www.atgc.org/GenoPix_2D_Plotter/
http://www.atgc.org/XLinkage/MadMapper/
http://www.atgc.org/TkLife/
PhD in Genetics. 1996. Wageningen Agricultural University
[ http://www.wau.nl/ ], The Netherlands.
M.S. in Chemistry. 1987. St Petersburg State University
[ http://www.spbu.ru/ ], Russia
Professional Experience:
2002 - current
Bioinformatics Specialist, UC Davis Genome Center.
Development of strategies for large-scale data handling, data analysis, and presentation;
managing multiple projects, training software developers, coordination of processes with lab scientists.
Generation of genetic databases (in mySQL) [ http://cgpdb.ucdavis.edu/sitemap.html ].
Development of software applications for data analysis, visualization, and presentation.
High-throughput EST/gene data processing and analysis.
Development of tools to validate and visualize high-density genetic maps [ http://www.atgc.org/XLinkage/MadMapper/ ].
SFP (single feature polymorphism) and eQTL mapping using Affymetrix chip expression data for Arabidopsis RILs [ http://elp.ucdavis.edu/ ].
Design and analysis of custom Affymetrix genome chips.
2000 - 2002
Postdoctoral fellow, Department of Vegetable Crops, UC Davis.
Studying the function of plant protein kinases and NBS-LRR genes (plant resistance to pathogens).
[ http://www.atgc.org/PhyloGrapher/Graph_Ath_NBS.html and http://niblrrs.ucdavis.edu/ ]
1996 - 2000
Postdoctoral fellow, UC Davis School of Medicine.
1. Chromosome structure in sperm cells.
Analyzed chromosome telomere length in human populations and telomere-binding protein(s) in bovine.
[ http://www.atgc.org/Presentation/Slide04.html ]
2. Genetics of autoimmune diseases (lupus) in human.
Performed data collection, processing, analysis, and genetic mapping.
[ The presentation of this project is available at http://www.atgc.org/Presentation/Genotyping_TDT.html (slides 5 to 36) ]
1991 - 1996
PhD student, Wageningen Agricultural University.
Plant-Microbe interaction, host specific interaction between Pea and rhizobia,
fine genetic mapping of plant genes involved into symbiosis.
[ http://www.atgc.org/Presentation/Slide02.html ]
Selected Publications:
A high-density, integrated genetic linkage map of lettuce (Lactuca spp.).
Theor Appl Genet. 2007 Sep 8; [Epub ahead of print]
[ PubMed:
17828385 ]
Conserved Ortholog Sets in forest trees.
Tree Genetics and Genomes. 2006 3:61-70
[ Abstract:
www.springerlink.com
Analyses of Synteny between Arabidopsis thaliana and Species in the Asteraceae
Reveal a Complex Network of Small Syntenic Segments and Major Chromosomal
Rearrangements.
Genetics. 2006 Aug;173(4):2227-2235. Epub 2006 Jun 18.
[ PubMed:
16783026 ]
High-density haplotyping with microarray-based expression and single feature
polymorphism markers in Arabidopsis.
Genome Res. 2006 Jun;16(6):787-795. Epub 2006 May 15.
[ PubMed:
16702412 ]
Functional analysis of the plant disease resistance gene Pto using DNA shuffling.
J Biol Chem. 2005 280(24): 23073-23083. Epub 2005 Mar 23.
[ PubMed:
15790558 ]
DiagHunter and GenoPix2D: programs for genomic comparisons, large-scale homology discovery and visualization.
Genome Biol. 2003;4(10):R68.
[ PubMed:
14519203 ]
Genome-wide analysis of NBS-LRR-encoding genes in Arabidopsis.
Plant Cell. 2003 Apr;15(4):809-834.
[ PubMed:
12671079 ]
GenomePixelizer-a visualization program for comparative genomics within and between species.
Bioinformatics 2002 18: 335-336.
[ PubMed:
11847088 ]
Identification and characterization of a bovine sperm protein that binds specifically to single-stranded telomeric deoxyribonucleic acid.
Biol Reprod. 2000 Feb;62(2):340-346.
[ PubMed:
10642571 ]
Increased telomere size in sperm cells of mammals with long terminal (TTAGGG)n arrays.
Mol Reprod Dev. 1998 Sep;51(1): 98-104.
[ PubMed:
9712323 ]
The pea early nodulin gene PsENOD7 maps in the region of linkage group I containing sym2 and leghaemoglobin.
Plant Mol Biol. 1996 Apr;31(1): 149-156.
[ PubMed:
8704148 ]
Selected Posters and Presentations:
PAG-15, January 13-17, 2007:
Development And Exploitation Of A Lettuce (Lactuca sativa) 6.6 Million Feature Affymetrix Genechip For Massively Parallel Genotyping And Gene Expression Analysis
[ http://www.intl-pag.org/15/abstracts/PAG15_P03e_174.html ]
María José Truco, Dean Lavelle, Leah McHale, Jason Argyris, David Caldwell, Marta Matvienko, Alex Kozik, Oswaldo Ochoa,
Smitha Mathrakott, Kent Bradford, Loren Rieseberg, Steve Knapp, Rick Kesseli, David Still, Richard Michelmore
The Compositae Genome Project
[ http://www.intl-pag.org/15/abstracts/PAG15_P05r_646.html ]
Allen Van Deynze, Thea Wilkins, Kevin Stoffel, Mike Lee, David Stelly, Alex Kozik
A Set Of Informative Markers Designed Specifically For Breeding Cotton
[ http://www.intl-pag.org/15/abstracts/PAG15_P05r_657.html ]
Tadeusz Wroblewski, Boris Vinatzer, Katherine S Caldwell, Ursula Piskurewicz, Keri A Cavanaugh, Joanna Jelenska,
Gail Teitzel, Leah K McHale, Huaqin Xu, Alexander Kozik, Oswaldo Ochoa, Luis A Williams, Jean T Greenberg, Richard W Michelmore
Comparative Large-Scale Analysis Of Resistance Gene Evolution
[ http://www.intl-pag.org/15/abstracts/PAG15_P07b_766.html ]
Madmapper And Checkmatrix - Python Scripts To Infer Orders Of Genetic Markers And For Visualization And Validation Of Genetic Maps And Haplotypes
[ http://www.intl-pag.org/14/abstracts/PAG14_C013.html ]
Development Of A Lettuce (Lactuca sativa) 6.6 Million Feature Affymetrix Genechip For Massively Parallel Genotyping And Gene Expression Analysis
[ http://www.intl-pag.org/14/abstracts/PAG14_P183.html ]
Comparative EST Sequencing Of Seventeen Compositae Species
[ http://www.intl-pag.org/14/abstracts/PAG14_P672.html ]
High-Density Haplotyping With Microarray-Based Single Feature Polymorphism Markers In Arabidopsis
[ http://www.intl-pag.org/14/abstracts/PAG14_P751.html ]
Gene Expression Markers: Using Transcript Levels Obtained From Microarrays To Genotype A Segregating Population
[ http://www.intl-pag.org/14/abstracts/PAG14_P761.html ]
Lettuce Genomics And Exploitation Of Information Generated By The Compositae Genome Project
[ http://www.intl-pag.org/14/abstracts/PAG14_W87.html ]
High-Throughput Mapping Pipeline Of EST Based Sequences On Lettuce Genome. Genetic Map Validation, Visualization And Web Presentation
[ http://www.intl-pag.org/pag/13/abstracts/PAG13_P250.html ]
Biologist-Friendly Pipeline For Processing And Masking Sequences
[ http://www.intl-pag.org/pag/13/abstracts/PAG13_P042.html ]
The Genetic Architecture Of Disease Resistance In Lactuca sativa
[ http://www.intl-pag.org/pag/13/abstracts/PAG13_W069.html ]
Identifying And Characterizing Regions Of Synteny Between Lettuce, Sunflower And Arabidopsis
[ http://www.intl-pag.org/pag/13/abstracts/PAG13_W070.html ]
ANALYSIS AND VISUALIZATION OF SINGLE COPY ORTHOLOGS IN ARABIDOPSIS, LETTUCE, SUNFLOWER AND OTHER PLANT SPECIES
[ http://www.intl-pag.org/pag/12/abstracts/P5a_PAG12_345.html ]
IDENTIFICATION AND MAPPING OF CANDIDATE GENES INVOLVED IN DISEASE RESISTANCE IN LETTUCE
[ http://www.intl-pag.org/pag/12/abstracts/P5q_PAG12_749.html ]
CANDIDATE GENE ANALYSIS FOR AGRICULTURALLY IMPORTANT TRAITS IN LETTUCE
[ http://www.intl-pag.org/pag/12/abstracts/W17_PAG12_56.html ]
ANALYSIS OF LETTUCE AND SUNFLOWER ESTS FROM THE COMPOSITAE GENOME PROJECT
[ http://www.intl-pag.org/pag/11/abstracts/W15_W97_XI.html ]
LETTUCE/SUNFLOWER EST CGPDB PROJECT: DATA ANALYSIS, ASSEMBLY VISUALIZATION AND VALIDATION
[ http://www.intl-pag.org/pag/11/abstracts/P10b_P886_XI.html ]
GENERATION OF CANDIDATE GENE MOLECULAR MARKERS IN LETTUCE FROM ASSEMBLED EST SEQUENCES IN THE COMPOSITAE GENOME PROJECT
[ http://www.intl-pag.org/pag/11/abstracts/P5q_P691_XI.html ]
COMPARISON OF ARABIDOPSIS VS. YEAST, HUMAN, AND WORM GENOMES
[ http://www.intl-pag.org/pag/11/abstracts/P3a_P138_XI.html ]
SIMPLE SEQUENCE REPEATS MINED FROM SUNFLOWER EXPRESSED SEQUENCE TAGS
[ http://www.intl-pag.org/pag/11/abstracts/P3b_P186_XI.html ]
GenomePixelizer - A VISUALIZATION TOOL FOR COMPARATIVE GENOMICS WITHIN AND BETWEEN SPECIES
[ http://www.intl-pag.org/pag/10/abstracts/PAGX_P788.html ]
COMPOSITDB: THE COMPOSITAE GENOME DATABASE
[ http://www.intl-pag.org/pag/10/abstracts/PAGX_P818.html ]
MAXIMIZING GENE DISCOVERY IN LETTUCE AND SUNFLOWER
[ http://www.intl-pag.org/pag/10/abstracts/PAGX_W73.html ]