ALEXANDER KOZIK
PROJECTS

Past (* - September 2000)**

My Education
MS in Chemistry, Russia.
PhD in Molecular Biology, The Netherlands.
Post doctoral project - UC Davis.
Slide_01
PhD project in the field of Plant-Microbe interaction.
Wageningen Agricultural University, The Netherlands,
Dr. Ton Bisseling's lab : Slide_02
Host specific interaction between Pea and rhizobia: Slide_03
First Post doctoral project
Telomere - binding protein(s) in bull sperm
UC Davis, School of Medicine : Slide_04
Second Post doctoral project
Genetics of autoimune diseases in human
UC Davis, Dr. Mike Seldin's lab : Slide_05
Systemic lupus erythematosus (SLE): Slide_06
Genes which were involved
into genotyping of SLE : Slide_07
Transmission - Disequilibrium Test as
a tool to detect linkage (association) between
complex disease and a genetic marker : Slide_08
Trios, preferential transmission of specific allele(s)
from parents to to affected child : Slide_09
Principles of Genotyping using SNPs : Slide_10
Strategy of Genotyping : Slide_11
Sample handling and dataflow (plate format) : Slide_12
Sample handling and dataflow (devices) : Slide_13
Low cost high throughput genotyping and sequencing : Slide_14
Multiplexing of different markers : Slide_15
Single base extension : Slide_16
"Minus One" Method : Slide_17
Example of GeneScan file (paradise) : Slide_18
Example of GeneScan file (hell) : Slide_19
Example of GeneScan file (real life) : Slide_20
Example of GeneScan file (allele dropout, insertion/deletion, real life) : Slide_21
Example of GeneScan file (allele dropout, repeats, real life) : Slide_22
Principles of SNPs searching and validation : Slide_23
Example of alignment of DNA sequences analyzed by
Phred, Phrap and PolyPhred and viewed in Consed : Slide_24
Examples of chromatograms, SNP validation
forward direction: Slide_25
Examples of chromatograms, SNP validation
reverse direction : Slide_26
Examples of chromatograms, SNP validation
two different alleles, single nucleotide insertion-deletion : Slide_27
Examples of chromatograms, SNP validation
Single nucleotide insertion-deletion (heterozygote) : Slide_28
Genotyping, example of separation of two alleles
with single nucleotide insertion-deletion : Slide_29
Example of fake SNP : Slide_30
Examples of chromatograms of fake SNP : Slide_31
Data management, data flow : Slide_32
Screenshot of mySQL database server
with PHP support : Slide_33
Screenshot of mySQL database server
with PHP support : Slide_34
Screenshot of mySQL database server
with PHP support : Slide_35
Hardware and software environment : Slide_36
Acknowledgements : Slide_37